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SAY NO TO EARLY SPAY NEUTER
Article on Early Spay Neuter.
A very legitimate concern, pet overpopulation, has been the primary driving force behind 30 years of national and local spay/neuter campaigns.
When it comes to deciding at what age a companion animal should be sterilized, the standard for most spay/neuter campaigns has been sooner rather than later. This is especially true in the case of adoptable abandoned and rescued pets that wind up in shelters and foster care.
Recently, however, some animal health care experts have begun to question whether early sterilization is a good idea for every pet.
Dr. Alice Villalobos, a well-known pioneer in the field of cancer care for companion animals, asks the question:
“But what if large-scale studies found that Early Spay Neuter jeopardizes the health of our pets?”
“What if we found enough epidemiological evidence that early neutering of pet dogs may open them to orthopedic, behavioral, immunologic and oncologic issues?”
Back in 1977, Dr. Villalobos founded a rescue organization called the Peter Zippi Fund for Animals, which has to date rescued and re-homed nearly 12,000 pets. Her organization was one of thousands that looked at the tragic situation in U.S. shelters and determined early spay/neuter was the best way to lessen the suffering and ultimate euthanasia of so many feral and abandoned animals.
As a veterinary oncologist and founder of the pet hospice program Pawspice, Dr. Villalobos concedes, “It is earth shattering to consider that some of the cancers we have been battling may have been enhanced by early neutering instead of the reverse.”
Veterinary Practice News
Dr. Becker’s Comments:
It’s unfortunately true that a growing body of research is pointing to early sterilization as the common denominator for development of several debilitating and life-threatening canine diseases.
On one hand, we certainly want to know what’s causing our precious canine companions to develop disease. On the other hand, it’s troubling to learn a procedure we’ve historically viewed as life-saving and of value to the pet community as a whole, has likely played a role in harming the health of some of the very animals we set out to protect.
The same amount of evidence has not been compiled for Early Spay Neuter of cats, but it’s not clear how well the subject is being studied for kitties. Funding for research into feline health issues falls well below dollars allocated for their canine counterparts.
A Veterinary Medical Database search of the years 1982 to 1995 revealed that in dogs with tumors of the heart, the relative risk for spayed females was over four times that of intact females.
For the most common type of cardiac tumor, hemangiosarcoma (HAS), spayed females had a greater than five times risk vs. their intact counterparts. Neutered male dogs had a slightly higher risk than intact males.
The study concluded that, “… neutering appeared to increase the risk of cardiac tumor in both sexes. Intact females were least likely to develop a cardiac tumor, whereas spayed females were most likely to develop a tumor. Twelve breeds had greater than average risk of developing a cardiac tumor, whereas 17 had lower risk.”
In a study of Rottweilers published in 2002, it was established the risk for bone sarcoma was significantly influenced by the age at which the dogs were sterilized.
For both male and female Rotties spayed or neutered before one year of age, there was a one in four lifetime risk for bone cancer, and the sterilized animals were significantly more likely to develop the disease than intact dogs of the same breed.
In another study using the Veterinary Medical Database for the period 1980 through 1994, it was concluded the risk for bone cancer in large breed, purebred dogs increased twofold for those dogs that were also sterilized.
It’s commonly believed that neutering a male dog will prevent prostatic carcinoma (PC) – cancer of the prostate gland.
But worthy of note is that according to one study conducted at the College of Veterinary Medicine at Michigan State University, “…castration at any age showed no sparing effect on the risk of development of PC in the dog.”
This was a small study of just 43 animals, however. And researchers conceded the development of prostate cancer in dogs may not be exclusively related to the hormones produced by the testicles. Preliminary work indicates non-testicular androgens exert a significant influence on the canine prostate.
Abnormal Bone Growth and Development
Studies done in the 1990?s concluded dogs spayed or neutered under one year of age grew significantly taller than non-sterilized dogs or those not spayed/neutered until after puberty. And the earlier the spay/neuter procedure, the taller the dog.
Research published in 2000 in the Journal of Pediatric Endocrinology and Metabolism may explain why dogs sterilized before puberty are inclined to grow abnormally:
At puberty, estrogen promotes skeletal maturation and the gradual, progressive closure of the epiphyseal growth plate, possibly as a consequence of both estrogen-induced vascular and osteoblastic invasion and the termination of chondrogenesis.
In addition, during puberty and into the third decade, estrogen has an anabolic effect on the osteoblast and an apoptotic effect on the osteoclast, increasing bone mineral acquisition in axial and appendicular bone.
It appears the removal of estrogen-producing organs in immature dogs, female and male, can cause growth plates to remain open. These animals continue to grow and wind up with abnormal growth patterns and bone structure. This results in irregular body proportions.
According to Chris Zink, DVM:
“For example, if the femur has achieved its genetically determined normal length at 8 months when a dog gets spayed or neutered, but the tibia, which normally stops growing at 12 to 14 months of age continues to grow, then an abnormal angle may develop at the stifle. In addition, with the extra growth, the lower leg below the stifle likely becomes heavier (because it is longer), and may cause increased stresses on the cranial cruciate ligament.”
Higher Rate of ACL Ruptures
A study conducted at Texas Tech University Health Sciences Center on canine anterior cruciate ligament (ACL) injuries concluded that spayed and neutered dogs had a significantly higher incidence of ACL rupture than their intact counterparts. And while large breed dogs had more ACL injuries, sterilized dogs of all breeds and sizes had increased rupture rates.
In a retrospective cohort study conducted at Cornell University’s College of Veterinary Medicine, and published in the Journal of the American Veterinary Medical Association, results showed that both male and female dogs sterilized at an early age were more prone to hip dysplasia.
Other Early-Age Spay/Neuter Health Concerns
Early Testicle removal is commonly associated with urinary incontinence in female dogs and has been linked to increased incidence of urethral sphincter incontinence in males.
Early Spay and Neuter with Golden Retrievers are more likely to develop hypothyroidism.
A cohort study of shelter dogs conducted by the College of Veterinary Medicine at Texas A&M University concluded that infectious diseases were more common in dogs that were sterilized at less than 24 weeks of age.
The AKC’s Canine Health Foundation issued a report pointing to a higher incidence of adverse reactions to vaccines in sterilized dogs.
Among the reports and studies pointing to health concerns associated with early spaying and neutering, you can also find mention of increased incidence of behavioral problems including:
Undesirable sexual behaviors
Risks versus Benefits of Early Sterilization
Recent results from research funded by the AKC Canine Health Foundation have the potential to significantly impact recommendations for spaying and neutering dogs in the United States. Most dogs in the United States are spayed or neutered, and for years the procedures have been completed prior to maturity. The study, published in the prominent, open-access journal PLOS One, suggests that veterinarians should be more cautious about the age at which they spay and neuter in order to protect the overall health of dogs.
A team of researchers led by Dr. Benjamin L. Hart at the University of California, Davis has completed the most detailed study performed to date that evaluates incidence of cancer diagnoses and joint problems in one breed -- Golden Retrievers -- by neuter status: early (before 12 months old), late (12 months or older), and intact. Consistent with previous studies on the topic, the results showed an increased likelihood of hemangiosarcoma, lymphoma, mast cell tumors, and canine cruciate ligament (CCL) rupture in neutered dogs.
The most profound observations were in hip dysplasia in male dogs when comparing early and late neutering. The risk of development of hip dysplasia doubles, and disease occurs at a younger age in the early-neuter group compared to both the intact and late-neuter group. No occurrence of CCL disease was observed in intact male or intact female dogs, or in late-neutered females. In early-neutered dogs, the incidence of CCL was 5.1 percent in males and 7.7 percent in females, suggesting that neutering prior to sexual maturity significantly increases a dog’s risk of developing CCL disease. With respect to cancer, cases of lymphoma were 3-fold greater in the early-neutered males. Interestingly, incidence of mast cell tumors (male and female dogs) and hemangiosarcoma (female dogs only) were highest in the late-neuter group.
“Dr. Hart’s landmark study is the first to provide evidence for when to spay or neuter dogs. For years the veterinary community has been aware that early spay and neuter may impact orthopedic health in dogs. Through a very detailed analysis and inclusion of body condition score as a risk factor, Dr. Hart was able to show that timing of spay and neuter does indeed have health implications,” said Dr. Shila Nordone, Chief Scientific Officer for the AKC Canine Health Foundation.
“CCL disease is painful, debilitating, and costs dog owners $1 billion annually to treat. The AKC Canine Health Foundation is committed to funding research, like Dr. Hart’s study, that can lead to evidence-based health recommendations. Armed with prudent guidelines for when to spay and neuter dogs we will have a significant impact on the quality of life for dogs,” continued Dr. Nordone.
Importantly, the task at hand is now to determine if the observations in this study are indeed true across all breeds and mixed breeds of dogs. Dr. Hart is interested in continuing his work by studying Labrador Retrievers, German Shepherd Dogs, and Dachshunds. Additionally, gaps in knowledge continue to exist concerning the complex relationship between sex hormones and cancer.
Last summer the AKC Canine Health Foundation released a podcast interview with Dr. Hart on his early-spay and neuter research as part of a series dedicated to the health of the canine athlete. To listen to the podcast visit www.akcchf.org/canineathlete
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